1. What is Rituximab Dosing?

Rituximab is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. The standard dosing regimen is typically 375 mg/m² of body surface area (BSA) per infusion.

2. How Does the Calculator Work?

The calculator uses the simple formula:

Where:

• 375 — Standard dose per square meter (mg/m²)
• BSA — Body surface area in square meters (m²)

Explanation: The calculation multiplies the standard dose per square meter by the patient's body surface area to determine the total dose.

3. Importance of BSA-based Dosing

Details: BSA-based dosing helps individualize medication doses to account for differences in body size, ensuring adequate drug exposure while minimizing toxicity.

4. Using the Calculator

Tips: Enter the patient's BSA in square meters (m²). The value must be greater than 0. Common BSA ranges are 1.4-2.2 m² for adults.

5. Frequently Asked Questions (FAQ)

Q1: How is BSA typically calculated?
A: BSA is often calculated using formulas like the Mosteller formula: √([height(cm) × weight(kg)]/3600).

Q2: Are there fixed-dose regimens for rituximab?
A: Some protocols use fixed doses (e.g., 1000 mg) regardless of BSA, particularly in autoimmune diseases.

Q3: What's the typical infusion schedule?
A: For lymphoma, often weekly × 4 doses. For autoimmune diseases, often two doses 2 weeks apart, repeated every 6 months.

Q4: Are there maximum dose limits?
A: Some protocols cap the dose (e.g., maximum 1400 mg regardless of BSA calculation).

Q5: How should doses be rounded?
A: Typically to the nearest 100 mg, using the nearest vial size (100 mg or 500 mg vials available).