1. What is Rituximab 375 mg/m² Dosing?

Rituximab is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. The standard dosing regimen is 375 mg per square meter of body surface area (BSA).

2. How Does the Calculator Work?

The calculator uses the simple formula:

Where:

• 375 — Standard dose per square meter (mg/m²)
• BSA — Body Surface Area in square meters (m²)

Explanation: The total dose is calculated by multiplying the standard dose (375 mg) by the patient's body surface area.

3. Importance of BSA-based Dosing

Details: BSA-based dosing helps individualize medication doses to account for differences in patient size, improving efficacy while minimizing toxicity.

4. Using the Calculator

Tips: Enter the patient's BSA in m² (must be >0). The calculator will compute the total dose in milligrams.

5. Frequently Asked Questions (FAQ)

Q1: How is BSA typically calculated?
A: BSA is commonly calculated using the Mosteller formula: √(height in cm × weight in kg / 3600).

Q2: Are there maximum or minimum doses?
A: Some protocols specify maximum doses (e.g., not to exceed 1000 mg per dose), but this varies by indication.

Q3: How often is this dose given?
A: The frequency varies by indication - weekly for some regimens, monthly for others, or as a single dose.

Q4: Are dose adjustments needed for renal impairment?
A: Rituximab doesn't typically require dose adjustment for renal impairment as it's not primarily renally cleared.

Q5: What about pediatric patients?
A: The same 375 mg/m² dose is often used for children, but consult specific pediatric protocols.